The former foreign secretary told a conference in Manchester that he would enter the race to succeed Theresa May if a vacancy arises.
He called on the party to return to its traditional values of low tax, strong policing and not to follow the policies of the left-wing Labour Party.
The prime minister has promised to step down if parliament ratifies her Brexit deal.
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Several senior Conservatives are expected to enter the contest for the leadership, with the winner also becoming prime minister.
Mrs May has said she will resign once the House of Commons backs her Brexit deal with the EU.
